Reaper, wine, wineasio, and vsts without dongles/pace/macromedia etc usually work.
Specialty audio software like melodyne and autotune won't. I can use Native Instruments and IK Multimedia with reaper, as well as all U-he instruments, DiscoDSP, Alchemy, Wusikstation, EZ Drummer, Addictive Drums etc
reaper output is just another instrument to linux, so can be sent to more fx if desired,
and recorded alongside hydrogen sample-sequencer/drum machine, yoshimi/zynaddsubfx,
and phasex synthesizers, Pianoteq, Hexter-dssi dx7 wannabee, and the great but complex linuxsampler.
issue command regsvr32 wineasio.dll
run winecfg, in the audio tab, choose alsa
in the /home/you/.wine folder, create the path Program Files/Steinberg/VstPlugins,
and copy vst .dlls there. For installers, the simple command
Installing Reaper in /home/you will save time later, as you
configure the new system.
Installing Trillian, Superior drummer etc is the only way to know if they will install. If they don't
trash the registry with convolutions, they probably will work. If they install to just one or two folders,
you might get lucky and just manually drop them in the .wine folder equivalents. Worked OK
for Absynth5 and Service Center (but there were 5 or 6 folders scattered willy nilly around Xp
Start reaper by command wine REAPER/reaper.exe,
have it scan plugins, and play some instruments.
The IK and NI standalones also work well for me.